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.Management of IgA nephropathy: current perspective.

IgA nephropathy is a leading cause of end-stage renal disease. It has been estimated that it is responsible for the nephropathy in 15-20% of all cases of chronic glomerulonephritis in developed countries. Despite the fact that large-scale, well-designed clinical trials of various treatment modalities are lacking, there is a general consensus that some treatment is needed for most patients to prevent progression to end-stage renal disease. Most patients with IgA nephropathy have persistent heavy proteinuria for many years. However, the precise molecular mechanism of proteinuria in IgA nephropathy has not been fully determined. Several mechanisms have been proposed, including increased glomerular permeability to macromolecules such as albumin or immune complexes, direct toxicity of circulating immune complexes, or secondary to chronic tubulointerstitial damage. Because most patients with IgA nephropathy present with proteinuria and have normal renal function, pharmacologic therapy is important. A complete understanding of the molecular pathophysiology is important for the development of more effective therapies. Non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme (ACE) inhibitors, immunosuppressive therapy, and maintenance hemodialysis may be considered as initial therapy. Although the effectiveness of such therapy has not been completely determined, initial studies suggest that angiotensin II type 1 receptor blockers and ACE inhibitors are effective. The effectiveness of hemodialysis remains to be determined.This invention relates to the processing of semiconductor wafers for production of integrated circuits and, more particularly, to improved apparatus and methods for processing semiconductor wafers which utilize both pressure and heat.

Semiconductor wafers are processed for formation of integrated circuits by techniques which may involve material deposition, doping, etching, ion implantation and oxidation. The processing usually is carried out in a 0b46394aab

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