Matlab 2014a Licence File 156 Fix
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The second most frequently activated pathway was the AKT pathway, as noted above (Fig. 5B in File S2). This may reflect a role for AKT in many cellular functions, including metabolism, cell growth, and apoptosis [33]. By computational pathway analysis (Fig. 7B in File S2) we found that AKT activation involves at least six different substrates (AKTS9, AKTS10, AKTS12, PDPK1, PRAS40, S6, and RAPTOR), which are also regulated by other pathways, and five of these substrates are phosphorylated in response to TCR stimulation (AKTS9, AKTS10, AKTS12, PRAS40, and RAPTOR). AKT phosphorylation brings AKT-targeted molecules into proximity with each other, bringing components of the mTOR complex into contact [34] and may also be relevant to regulation of 14-3-3 proteins [35]. The functions of mTORC1 and AKT signaling include metabolism, cell growth, cell fate decision, and longevity [33].
We would like to thank Duan You for providing the MATLAB scripts and programs that were used in optimization, Erlijne van Oers for providing the Parsemotif package, and Stefan von Schmidding for technical assistance. This work received financial support from the European Research Council (ERC) Advanced Grant 242028-Negratn to Gilles A. Couairon and the Swiss National Science Foundation Professorship to Peter H. Seeburg. d2c66b5586
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